Cesar Valades-Cruz
Imaging methods
Measuring molecular orientation and nanoscale structure using polarized super-resolution microscopy.
Measuring molecular orientation and nanoscale structure using polarized super-resolution microscopy.
Quantitative nanoscale imaging of molecular orientation
Polarized super-resolution microscopy for imaging orientational order in biological structures
About: Long-standing collaboration with Sophie Brasselet’s team at Institut Fresnel, France. We develop polarization-based super-resolution methods to measure the nanoscale organization and 3D orientation of biological filaments such as actin networks.
Latest: Our new method 4polar3D, published in Nature Communications (2026), enables 3D orientation measurements of single molecules in dense actin structures using ratiometric polarization splitting — with minimal optical complexity and fast data processing. Read the paper →
Ultrastructure imaging